全身炎症
炎症
免疫系统
神经认知
免疫学
医学
病理生理学
心情
全身给药
神经科学
心理学
生物
认知
病理
精神科
生物技术
体内
作者
Manfred Schedlowski,Harald Engler,Jan‐Sebastian Grigoleit
标识
DOI:10.1016/j.bbi.2013.09.015
摘要
Systemic inflammation is among the most prominent and most frequently observed responses of the immune system. Over the past decades, it has become clear that inflammatory cytokines not only affect immune and metabolic functions but also cause a wide range of behavioral and mood changes. Based on experimental findings in animals and observations in clinical populations it has been hypothesized that inflammation-induced neurocognitive changes contribute to the pathophysiology of neuropsychiatric diseases. However, since certain aspects of human behavior cannot be modeled in laboratory animals, there is a need for human models of systemic inflammation. In this review, we summarize recent studies employing administration of endotoxin as a model to induce transient systemic inflammation in healthy human subjects.
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