化学
分子识别
氢键
超分子化学
分子
选择性
组合化学
溶剂
疏水效应
荧光
小分子
表面改性
有机化学
光化学
物理
催化作用
量子力学
作者
Guobao Huang,Shenghua Wang,Hua Zhu Ke,Liu‐Pan Yang,Wei Jiang
摘要
Selective recognition of neutral hydrophilic molecules in water is a challenge for supramolecular chemistry but commonplace in nature. By mimicking the binding pocket of natural receptors, endo-functionalized molecular tubes are proposed to meet this challenge. We found that two molecular tubes with inwardly directed hydrogen-bond donors recognize highly hydrophilic solvent molecules in water with high selectivity. In the complexes, hydrogen bonding occurs in the deep and hydrophobic cavity. The cooperative action between hydrogen bonding and hydrophobic effects accounts for the high affinity and selectivity. The molecular receptor is fluorescent and can detect concentrations of 1,4-dioxane—a known carcinogen and persistent environmental contaminant—in water at a limit of 119 ppb. The method simplifies the analytic procedure for this highly hydrophilic molecule.
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