Nanotechnology and immunoengineering: How nanotechnology can boost CAR-T therapy

嵌合抗原受体 纳米技术 癌症治疗 材料科学 免疫疗法 细胞疗法 癌症免疫疗法 医学 癌症 细胞 生物 内科学 遗传学
作者
Waqas Nawaz,Shijie Xu,Yanlei Li,Bilian Huang,Xilin Wu,Zhiwei Wu
出处
期刊:Acta Biomaterialia [Elsevier BV]
卷期号:109: 21-36 被引量:56
标识
DOI:10.1016/j.actbio.2020.04.015
摘要

Chimeric antigen receptor (CAR) therapy has achieved remarkable clinical efficacy against hematological cancers and has been approved by FDA for treatment of B-cell tumors. However, the complex manufacturing process and limited success in solid tumors hamper its widespread applications, thus prompting the development of new strategies for overcoming the abovementioned hurdles. In the last decade, nanotechnology has provided sustainable strategies for improving cancer immunotherapy through vaccine development and delivery of immunomodulatory drugs. Nanotechnology can boost CAR-T therapy and may overcome the existing challenges by emerging as a carrier for CAR-T therapy or in combination with CAR-T, it may inhibit solid tumors more effectively than conventional approaches. The revealing of cellular mechanisms, barriers and potential strategies that could be used to manipulate and/or modify cells would enable unprecedented advances in nanotechnology for biologics delivery. This review outlines the journey and barriers of nanoparticles (NPs) across the cell. Subsequently, the approaches to tackle the barriers and strategies to modulate NPs as a carrier for CAR-T therapy are discussed. Finally, the role of NPs in CAR-T therapy and the potential challenges are summarized. This review aims to provide the readers with a detailed overview of NP-based CAR-T therapy research and distil this information into an accessible form conducive to design desired CAR-T therapy using NP approach. Chimeric antigen receptor (CAR) T-cell therapy is the most vibrant field in immuno-oncology today, with enormous benefits to patients with B-cell malignancies. However, a rapid and straightforward procedure for CAR-T generation is an exigent need to broaden its therapeutic avenue. Nanotechnology has emerged as a novel alternative approach for CAR-T generation. To the best of our knowledge, this is the first in-depth review that briefly highlights the various aspects of nanotechnology in CAR-T therapy, including the strategies to brand NPs as an effective carrier for CAR cargo, its potential advantages, challenges, and future roadmap. It provides readers with a detailed overview of NP-based CAR-T therapy research, and researchers would be able to distill this information into an accessible form conducive to design the desired CAR therapy using the nanotechnology approach.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Passskd完成签到,获得积分10
1秒前
fang应助科研通管家采纳,获得10
2秒前
山野村夫应助科研通管家采纳,获得10
2秒前
爆米花应助科研通管家采纳,获得10
2秒前
予修应助科研通管家采纳,获得10
2秒前
liliflower应助科研通管家采纳,获得10
2秒前
伶俐乐菱应助科研通管家采纳,获得10
2秒前
伶俐乐菱应助科研通管家采纳,获得10
2秒前
FAN应助科研通管家采纳,获得10
2秒前
FashionBoy应助科研通管家采纳,获得10
2秒前
天天快乐应助科研通管家采纳,获得10
2秒前
FAN应助科研通管家采纳,获得10
2秒前
2秒前
李治海发布了新的文献求助10
3秒前
zhuzhu完成签到,获得积分10
4秒前
星辰大海应助jiaolulu采纳,获得10
4秒前
5秒前
颖宝老公完成签到,获得积分0
5秒前
清爽夜雪完成签到,获得积分0
6秒前
量子星尘发布了新的文献求助10
6秒前
大翟完成签到,获得积分10
8秒前
不远完成签到,获得积分10
9秒前
冯珂完成签到 ,获得积分10
11秒前
Graham完成签到,获得积分10
11秒前
稳重乌冬面完成签到 ,获得积分10
13秒前
一苇以航完成签到 ,获得积分10
14秒前
戚雅柔完成签到 ,获得积分10
14秒前
vsvsgo完成签到,获得积分10
15秒前
米奇完成签到 ,获得积分10
15秒前
加一点荒谬完成签到,获得积分10
15秒前
15秒前
一一一给轻松白桃的求助进行了留言
17秒前
zz2905完成签到,获得积分10
17秒前
小超人完成签到 ,获得积分10
18秒前
香蕉初瑶完成签到,获得积分10
18秒前
meimei完成签到 ,获得积分10
18秒前
儒雅的菠萝吹雪完成签到,获得积分10
19秒前
19秒前
20秒前
水寒完成签到,获得积分10
20秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038235
求助须知:如何正确求助?哪些是违规求助? 3575992
关于积分的说明 11374009
捐赠科研通 3305760
什么是DOI,文献DOI怎么找? 1819276
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022