细胞凋亡
线粒体
电压依赖性阴离子通道
细胞
癌症研究
细胞生长
生物
车站3
细胞生物学
化学
细菌外膜
生物化学
基因
大肠杆菌
作者
Haili Lü,Quihang Zhang,Bo Yan
出处
期刊:PubMed
日期:2012-04-01
卷期号:26 (7): 316-8
被引量:1
摘要
To investigate the changes of mitochondrion by transferring antisense oligodeoxynucleotide Stat3 into laryngeal carcinoma Hep-2 cell, for elucidating the mechanism of laryngeal carcinoma Hep-2 cell apoptosis, for developing more effective treatment for laryngeal cancer.The designed Stat3 ASODN was transferred into laryngeal carcinoma Hep-2 cell by lipofection. Mitochondrion membrane potential, VDAC and Cyt-c were detected for determining the changes of mitochondrion.MMP was fell, Cyt-c and VDAC were increased with the heighten concentration of ASODN.Mitochondria approach play an important role in the apoptosis mechanism of human Hep-2 cell by Stat3. This research elucidated the regulating mechanism of Hep-2 cell proliferation by Stat3, provided a new research focus for clinical therapy.
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