2021 American Thyroid Association Guidelines for Management of Patients with Anaplastic Thyroid Cancer

医学 指南 分级(工程) 甲状腺癌 甲状腺间变性癌 内科学 重症监护医学 梅德林 医学物理学 甲状腺 病理 政治学 工程类 土木工程 法学
作者
Keith C. Bible,Electron Kebebew,James D. Brierley,Juan P. Brito,Maria E. Cabanillas,T. Justin Clark,Antonio Di Cristofano,Robert L. Foote,Thomas J. Giordano,Jan L. Kasperbauer,Kate Newbold,Yuri E. Nikiforov,Gregory W. Randolph,Mitchell Rosenthal,Anna M. Sawka,Manisha H. Shah,Ashok R. Shaha,Robert C. Smallridge,Carol K. Wong-Clark
出处
期刊:Thyroid [Mary Ann Liebert]
卷期号:31 (3): 337-386 被引量:389
标识
DOI:10.1089/thy.2020.0944
摘要

Background: Anaplastic thyroid cancer (ATC) is a rare but highly lethal form of thyroid cancer. Since the guidelines for the management of ATC by the American Thyroid Association were first published in 2012, significant clinical and scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, and researchers on published evidence relating to the diagnosis and management of ATC. Methods: The specific clinical questions and topics addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of the Task Force members (authors of the guideline). Relevant literature was reviewed, including serial PubMed searches supplemented with additional articles. The American College of Physicians Guideline Grading System was used for critical appraisal of evidence and grading strength of recommendations. Results: The guidelines include the diagnosis, initial evaluation, establishment of treatment goals, approaches to locoregional disease (surgery, radiotherapy, targeted/systemic therapy, supportive care during active therapy), approaches to advanced/metastatic disease, palliative care options, surveillance and long-term monitoring, and ethical issues, including end of life. The guidelines include 31 recommendations and 16 good practice statements. Conclusions: We have developed evidence-based recommendations to inform clinical decision-making in the management of ATC. While all care must be individualized, such recommendations provide, in our opinion, optimal care paradigms for patients with ATC.
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