微晶纤维素
极限抗拉强度
减压
材料科学
复合材料
模具(集成电路)
结构工程
纤维素
工程类
医学
外科
纳米技术
化学工程
作者
Vincent Mazel,E. Yost,Kellie K. Sluga,Karthik Nagapudi,Ariel R. Muliadi
标识
DOI:10.1016/j.ijpharm.2024.124150
摘要
This study investigates decompression and ejection conditions on tablet characteristics by comparing compact densities and tensile strengths made using regular rigid dies and custom-built die systems that enable triaxial decompression. Die-wall pressure evolution during decompression and ejection stresses did not meaningfully impact the density and tensile strength of the materials tested: microcrystalline cellulose, crystalline lactose monohydrate, and mannitol. Furthermore, the apparent differences in tensile strength between rectangular cuboids and cylindrical compacts are unrelated to decompression and ejection conditions, but rather a consequence of their shapes and of the test configurations. This suggests that elastic and plastic deformations that may occur during decompression and ejection are not significantly influenced by die-wall pressure evolution. We thus conclude that while triaxial decompression and constraint-free ejection may allow the production of defect-free compacts for materials that otherwise are defect prone using a rigid die, they seem to pose no benefits when the materials already produce defect-free compacts using a rigid die.
科研通智能强力驱动
Strongly Powered by AbleSci AI