Exosomes: A promising new strategy for treating osteoporosis in the future

微泡 骨质疏松症 医学 计算生物学 纳米技术 重症监护医学 生物信息学 生物 内科学 小RNA 材料科学 遗传学 基因
作者
Sheng Hu,Yujie Liang,X. Pan
出处
期刊:Journal of Drug Delivery Science and Technology [Elsevier BV]
卷期号:: 105571-105571
标识
DOI:10.1016/j.jddst.2024.105571
摘要

Osteoporosis (OP) is one of the most common chronic diseases, characterized by decreased bone mass, increased bone fragility, and the destruction of bone microstructure. Current methods of treating OP face challenges, including poor therapeutic effects, obvious side effects, an inability to improve osteoblast proliferation and differentiation, and difficulty in fundamentally restoring the process of OP. Therefore, there is a need for new treatment strategies. As endogenous extracellular vesicles secreted by eukaryotic cells, exosomes participate in intercellular communication during bone remodeling. The contents of exosomes include proteins, DNA, microRNAs, etc., playing an important role in the pathogenesis of osteoporosis and osteogenesis regulation. Therefore, in this review, we emphasize the role of exosomes in the pathogenesis of osteoporosis, with a focus on their potential in reversing osteoporosis and their therapeutic efficacy. Additionally, we discuss the biological characteristics of exosomes, methods of extraction, the impact of exosomes from various sources on bone metabolism regulation, and their relevant applications. Furthermore, we explore the combination of exosomes with different bone tissue engineering materials and the latest research on the mechanisms and applications of exosome-targeted therapy for osteoporosis. Finally, the challenges and future perspectives of exosomes in the diagnosis and therapy of OP are discussed, providing important insights into the accurate clinical treatment of OP.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
1秒前
daaarrr完成签到,获得积分10
4秒前
非一发布了新的文献求助10
7秒前
7秒前
8秒前
9秒前
乐乐应助事在人为采纳,获得10
10秒前
11秒前
jisujun完成签到,获得积分20
11秒前
41应助momo采纳,获得10
12秒前
DijiaXu应助jszhoucl采纳,获得10
14秒前
热爱科研的小白鼠完成签到,获得积分10
14秒前
14秒前
爱穿毛袜完成签到,获得积分10
15秒前
大模型应助LJJ采纳,获得10
15秒前
spirit完成签到 ,获得积分10
16秒前
思源应助hhh采纳,获得10
16秒前
17秒前
正直的魔镜完成签到 ,获得积分10
18秒前
20秒前
KM比比发布了新的文献求助10
21秒前
如此完成签到,获得积分10
21秒前
qq完成签到 ,获得积分10
22秒前
qqq发布了新的文献求助10
23秒前
火星上鑫鹏完成签到,获得积分10
23秒前
事在人为发布了新的文献求助10
23秒前
沉默的婴发布了新的文献求助20
24秒前
杨涵完成签到 ,获得积分10
25秒前
ponysmile完成签到,获得积分20
26秒前
葡萄完成签到,获得积分10
26秒前
26秒前
共享精神应助卖萌的秋田采纳,获得10
27秒前
28秒前
阿钉发布了新的文献求助10
30秒前
30秒前
tannie完成签到 ,获得积分10
32秒前
34秒前
LJJ发布了新的文献求助10
35秒前
37秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173