圣杯
癌基因
调节器
主调节器
癌症
癌症研究
药品
药物开发
靶向治疗
抗癌药物
临床试验
医学
生物
计算生物学
生物信息学
基因
药理学
遗传学
转录因子
内科学
细胞周期
计算机科学
万维网
作者
Danielle F. Atibalentja,Anja Deutzmann,Dean W. Felsher
标识
DOI:10.1016/j.trecan.2024.03.009
摘要
The MYC proto-oncogene encodes a master transcriptional regulator that is frequently dysregulated in human cancer. Decades of efforts have failed to identify a MYC-targeted therapeutic, and this is still considered to be a holy grail in drug development. We highlight a recent report by Garralda et al. of a Phase 1 clinical trial of OMO-103 in patients with solid malignancies.
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