Liver macrophages and sinusoidal endothelial cells execute vaccine-elicited capture of invasive bacteria

调理素 抗体 免疫系统 免疫 抗体调理 生物 免疫学 免疫球蛋白G 微生物学 补体受体 补体系统 受体 Fc受体 生物化学
作者
Juanjuan Wang,Haoran An,Ming Wei Ding,Yanhong Liu,Shaomeng Wang,Qian Jin,Qi Wu,Haodi Dong,Qile Guo,Xianbin Tian,Jiankai Liu,Jingfei Zhang,Tao Zhu,Junqiang Li,Zhujun Shao,David E. Briles,Jan‐Willem Veening,Haifa Zheng,Linqi Zhang,Jing‐Ren Zhang
出处
期刊:Science Translational Medicine [American Association for the Advancement of Science (AAAS)]
卷期号:15 (727) 被引量:5
标识
DOI:10.1126/scitranslmed.ade0054
摘要

Vaccination has substantially reduced the morbidity and mortality of bacterial diseases, but mechanisms of vaccine-elicited pathogen clearance remain largely undefined. We report that vaccine-elicited immunity against invasive bacteria mainly operates in the liver. In contrast to the current paradigm that migrating phagocytes execute vaccine-elicited immunity against blood-borne pathogens, we found that invasive bacteria are captured and killed in the liver of vaccinated host via various immune mechanisms that depend on the protective potency of the vaccine. Vaccines with relatively lower degrees of protection only activated liver-resident macrophage Kupffer cells (KCs) by inducing pathogen-binding immunoglobulin M (IgM) or low amounts of IgG. IgG-coated pathogens were directly captured by KCs via multiple IgG receptors FcγRs, whereas IgM-opsonized bacteria were indirectly bound to KCs via complement receptors of immunoglobulin superfamily (CRIg) and complement receptor 3 (CR3) after complement C3 activation at the bacterial surface. Conversely, the more potent vaccines engaged both KCs and liver sinusoidal endothelial cells by inducing higher titers of functional IgG antibodies. Endothelial cells (ECs) captured densely IgG-opsonized pathogens by the low-affinity IgG receptor FcγRIIB in a “zipper-like” manner and achieved bacterial killing predominantly in the extracellular milieu via an undefined mechanism. KC- and endothelial cell–based capture of antibody-opsonized bacteria also occurred in FcγR-humanized mice. These vaccine protection mechanisms in the liver not only provide a comprehensive explanation for vaccine-/antibody-boosted immunity against invasive bacteria but also may serve as in vivo functional readouts of vaccine efficacy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
老肖应助小轩窗zst采纳,获得10
1秒前
2秒前
学材料的向日葵完成签到,获得积分10
2秒前
3秒前
风趣绯完成签到,获得积分20
4秒前
4秒前
6秒前
仙人掌完成签到,获得积分10
6秒前
9秒前
丁真真发布了新的文献求助10
9秒前
小南子发布了新的文献求助10
9秒前
10秒前
13秒前
赤和红叶完成签到 ,获得积分10
13秒前
13秒前
鸢尾发布了新的文献求助10
13秒前
14秒前
大个应助Guo采纳,获得10
14秒前
韦一宁完成签到,获得积分20
14秒前
smelong发布了新的文献求助10
16秒前
czagodlike发布了新的文献求助30
18秒前
Yi发布了新的文献求助10
19秒前
鸢尾完成签到,获得积分10
23秒前
完美世界应助lxxlxxlxx采纳,获得10
25秒前
科研通AI2S应助hkh采纳,获得10
28秒前
29秒前
清新的山芙完成签到,获得积分10
31秒前
等待寄云完成签到 ,获得积分10
32秒前
振耳欲聋的沉默完成签到,获得积分10
33秒前
cty666发布了新的文献求助10
33秒前
蓝白发布了新的文献求助10
34秒前
35秒前
39秒前
以恒之心发布了新的文献求助10
40秒前
嗯呐完成签到,获得积分10
40秒前
Ztt完成签到,获得积分10
40秒前
41秒前
丁昆发布了新的文献求助10
42秒前
CodeCraft应助不喜采纳,获得10
43秒前
天天快乐应助演员的太阳采纳,获得10
44秒前
高分求助中
The ACS Guide to Scholarly Communication 2500
Microlepidoptera Palaearctica, Volumes 1 and 3 - 13 (12-Volume Set) [German] 1122
The Data Economy: Tools and Applications 1000
Ethnicities: Media, Health, and Coping 700
书名《抗体药物研发》 560
Ожившие листья и блуждающие цветы. Практическое руководство по содержанию богомолов [Alive leaves and wandering flowers. A practical guide for keeping praying mantises] 500
Development of a new synthetic process for the synthesis of (S)-methadone and (S)- and (R)-isomethadone as NMDA receptor antagonists for the treatment of depression 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3092046
求助须知:如何正确求助?哪些是违规求助? 2744375
关于积分的说明 7579678
捐赠科研通 2395501
什么是DOI,文献DOI怎么找? 1270412
科研通“疑难数据库(出版商)”最低求助积分说明 614760
版权声明 598844