共价键
赖氨酸
配体(生物化学)
DNA
组合化学
化学
选择(遗传算法)
纳米技术
材料科学
计算机科学
生物化学
有机化学
氨基酸
人工智能
受体
作者
Haimei Wei,Tianyang Zhang,Yangfeng Li,Gong Zhang,Yizhou Li
标识
DOI:10.1002/asia.202300652
摘要
Covalent crosslinking probes have arisen as efficient toolkits to capture and elucidate biomolecular interaction networks. Exploiting the potential of crosslinking in DNA-encoded chemical library (DEL) selection methods significantly boosted bioactive ligand discovery in complex physiological contexts. Herein, we incorporated o-nitrobenzyl alcohol (o-NBA) as a photo-activated lysine-selective crosslinker into divergent DEL formats and achieved covalent capture of ligand-target interactions featuring improved crosslinking efficiency and site-specificity. In addition, covalent DEL selection was realized with the modularly designed o-NBA-functionalized mock libraries.
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