Assessment of anti-CD69 antibody therapy alone or in combination with anti-PD-1 in murine GBM
医学
抗体
抗体疗法
免疫学
单克隆抗体
作者
Michal Nisnboym,Chaim T. Sneiderman,Ambika P. Jaswal,Zujian Xiong,Sarah R. Vincze,ReidAnn E. Sever,Han Zou,Stephen C. Frederico,Sameer Agnihotri,Baoli Hu,Jan Drappatz,Ian F. Pollack,Gary Kohanbash,Itay Raphael
Background Glioblastoma (GBM) is an aggressive cancer with limited treatment options. Immunotherapy targeting CD69, an early activation marker on T cells, has shown promise in preclinical models of non-CNS malignancies. This study investigates anti-CD69 therapy alone or in combination with anti-PD-1 in a preclinical GBM model.