Intravenous Thrombolysis with Urokinase for Acute Ischemic Stroke

特奈特普酶 尿激酶 溶栓 医学 重症监护医学 冲程(发动机) 溶栓药 纤溶剂 临床实习 组织纤溶酶原激活剂 外科 内科学 物理疗法 心肌梗塞 机械工程 工程类
作者
Qiao Yue,Jing Wang,Thanh N. Nguyen,Lan Liu,Xunming Ji,Wenbo Zhao
出处
期刊:Brain Sciences [MDPI AG]
卷期号:14 (10): 989-989 被引量:1
标识
DOI:10.3390/brainsci14100989
摘要

Background: Intravenous thrombolysis is one of the most effective therapies for the treatment of acute ischemic stroke (AIS), with urokinase offering a cost-effective alternative to newer agents like alteplase and tenecteplase, especially in resource-limited settings. Methods: This review provides a comprehensive overview of the application of intravenous thrombolysis with urokinase for AIS in the clinical practice of stroke management, including the efficacy, safety, and cost-effectiveness of urokinase compared to other thrombolytic agents. Results: Urokinase, a first-generation thrombolytic drug, is a non-specific plasminogen activator that offers a cost-effective alternative. It has been used in clinical practice for over two decades to improve neurological outcomes in patients with AIS if administered within 6 h of ictus. Numerous studies have indicated that urokinase remains a viable option for patients who cannot access alteplase or tenecteplase because of economic constraints, time window limitations, availability, or other reasons. Conclusions: In low- and middle-income countries, urokinase is a cost-effective alternative thrombolytic drug. High-level evidence-based medical research is therefore urgently needed to confirm that urokinase is not inferior to new-generation thrombolytic drugs, and to assess whether it may even be superior in some patient populations.
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