Gas‐Controlled Self‐Assembly of Metallacycle‐Cored Supramolecular Star Polymer with Tunable Antibacterial Activity

Abstract Herein, a three‐armed amphiphilic metallacycle‐cored star supramolecular polymer ( Por‐MOM‐PDMAEMA ) has been designed and synthesized via highly efficient post‐assembly polymerization. This star polymer is further self‐assembled into nanoparticles of different sizes depending upon the experimental conditions. The gas‐controlled morphology transformation and tunable antibacterial activities of Por‐MOM‐PDMAEMA is systematically investigated and compared with metallacycle (MOM). The superior antibacterial activity of Por‐MOM‐PDMAEMA against multidrug‐resistant P. aeruginosa implies that the presence of photodynamic photosensitizer (Por) and cationic polymer chain will significantly enhance antibactericidal activity, which is mainly attributed to the synergistic effect of photosensitizer and polymer chain linked in one metallacycle core. By leveraging the unique properties of metallacycle and their dynamic response to gaseous stimuli, the antibacterial properties of the Por‐MOM‐PDMAEMA can be finely tuned in response to gas triggers.