材料科学
体内
生物医学工程
再生医学
组织工程
生物相容性材料
材料试验
纳米技术
干细胞
医学
细胞生物学
生物
生物技术
复合材料
作者
Joseph A. Sebastian,Eric M. Strohm,Jérôme Baranger,Olivier Villemain,Michael C. Kolios,Craig A. Simmons
出处
期刊:Biomaterials
[Elsevier]
日期:2023-02-16
卷期号:296: 122054-122054
被引量:9
标识
DOI:10.1016/j.biomaterials.2023.122054
摘要
Quantitative assessment of the structural, functional, and mechanical properties of engineered tissues and biomaterials is fundamental to their development for regenerative medicine applications. Ultrasound (US) imaging is a non-invasive, non-destructive, and cost-effective technique capable of longitudinal and quantitative monitoring of tissue structure and function across centimeter to sub-micron length scales. Here we present the fundamentals of US to contextualize its application for the assessment of biomaterials and engineered tissues, both in vivo and in vitro. We review key studies that demonstrate the versatility and broad capabilities of US for clinical and pre-clinical biomaterials research. Finally, we highlight emerging techniques that further extend the applications of US, including for ultrafast imaging of biomaterials and engineered tissues in vivo and functional monitoring of stem cells, organoids, and organ-on-a-chip systems in vitro.
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