原发性进行性失语
帕金森病
失语症
失用症
后皮质萎缩
心理学
失智症
医学
病理
神经科学
听力学
痴呆
疾病
作者
Martina Caccamo,Daniele Urso,Alfredo Gabriele Nanni,Valentina Gnoni,Alessia Giugno,Alessandra Vitulli,Davide Vilella,Chiara Zecca,Maria Teresa Dell’Abate,Antonio Anastasia,Roberto De Blasi,Alessandro Introna,Giancarlo Logroscino
出处
期刊:Journal of Alzheimer's disease reports
[IOS Press]
日期:2024-06-25
卷期号:8 (1): 1023-1030
摘要
The presence of parkinsonism features in primary progressive aphasia (PPA) is a subject of ongoing research. These features are usually more pronounced in the advanced stages of the disease, particularly in the non-fluent/agrammatic subtype, and are exceptionally rare in the logopenic variant (lvPPA). Here we report a case of a 63-year-old man presenting as language impairment, predominantly naming and word-finding difficulties, emerged alongside a left-sided internal tremor. Neurological examination revealed bilateral, left-side predominant rigidity, bradykinesia, and resting tremor. Notably, anosmia and constipation were present. Language assessments showed preserved single-word comprehension, object knowledge, and a minimal apraxia of speech, as well as sentence repetition issues. Neuroimaging and biomarker analysis supported a diagnosis of primary progressive logopenic aphasia with amyloid pathology co-existing with prominent and early parkinsonism. This case underlines the intricate relationship between language disorders, parkinsonism, and amyloid pathology in lvPPA.
科研通智能强力驱动
Strongly Powered by AbleSci AI