认知
韦氏成人智力量表
毒品天真
阳性与阴性症状量表
心理学
功能磁共振成像
精神分裂症(面向对象编程)
混淆
听力学
医学
精神科
临床心理学
精神病
内科学
神经科学
药品
作者
Wei Yan,Rongrong Zhang,Min Zhou,Shuiping Lu,Wenmei Li,Shusen Xie,Ning Zhang
出处
期刊:BMC Psychiatry
[Springer Nature]
日期:2020-06-05
卷期号:20 (1)
被引量:22
标识
DOI:10.1186/s12888-020-02692-z
摘要
Abstract Background Prior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, and illness duration. Relationships between ReHo measures and cognitive impairments in patients with drug-naive First-Episode Schizophrenia (dn-FES) are rarely reported. This study was conducted to explore the correlations between ReHo measures and cognitive deficits and clinical symptoms in patients with dn-FES. Methods A total of 69 patients with dn-FES and 74 healthy controls were recruited. MATRICS Consensus Cognitive Battery (MCCB), Wechsler Adult Intelligence Scale (WAIS), and Positive And Negative Syndrome Scale (PANSS) were used to assess cognitive function, Intelligence Quotient (IQ), and clinical symptoms, respectively. The correlations between ReHo maps and cognitive deficits and the severity of symptoms were examined using strict correlation analysis. Results ReHo values in right Middle Frontal Gyrus (MFG) and Superior Frontal Gyrus (SFG) increased in dn-FES group, whereas ReHo values in right cuneus decreased. Correlation analysis showed that the ReHo values in right MFG positively correlated with attention/vigilance impairments, social cognition deficits, and the severity of clinical manifestations. Conclusions These findings suggested that abnormal spontaneous activities in right MFG reflect illness severity and cognitive deficits, which also serve as a basis for establishing objective diagnostic markers and might be a clinical intervention target for treating patients with schizophrenia.
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