Integration of multiple key molecules in lung adenocarcinoma identifies prognostic and immunotherapeutic relevant gene signatures

钥匙(锁) 癌症研究 腺癌 生物 肺癌 计算生物学 医学 基因 肿瘤科 癌症 遗传学 生态学
作者
Qiong Wu,Lei Wang,Huagen Wei,Ben Li,Jiaming Yang,Zilin Wang,Jianfeng Xu,You Zhou,Bo Zhang
出处
期刊:International Immunopharmacology [Elsevier BV]
卷期号:83: 106477-106477 被引量:16
标识
DOI:10.1016/j.intimp.2020.106477
摘要

Although multiple key molecules in lung adenocarcinoma (LUAD) have been identified in recent years, the overall tumor microenvironment (TME) immune cell infiltration characterizations mediated by multiple key molecules remain little known. This study aimed to integrate the roles of multiple key molecules to evaluate patient prognosis and TME cell infiltration characterization as well as responses to immunotherapy. Using combined LUAD cancer cohorts with 228 normal samples and 913 tumor samples, we comprehensively dissected the differences of genomic and TME cell infiltration landscapes between normal lung tissues and tumor tissues. The single-sample gene-set enrichment analysis (ssGSEA) was used to quantify the relative abundance of 24 cell infiltration. The riskScore signature was constructed using a least absolute shrinkage and selection operator (LASSO) Cox regression mode. Seven novel key molecules with significantly up-regulated expression in LUAD were determined. Survival analyses revealed their important prognostic values. LUAD microenvironment presented a markedly decreased infiltration of immune cells compared to normal lung tissues. We found tumors with up-regulated expression of these key molecules exhibited a significantly decreased TME cell infiltration and increased immune checkpoint molecule expression. The high riskScore subtype was characterized by decreased innate and adaptive immune cell infiltration. Activation of p53 signaling pathway and regulator T cells were observed in the high riskScore subtype, which were regarded as T-cell suppressive and could be responsible for poorer prognosis in this subtype (HR 1.83(1.27–2.63)). Multivariate analyses demonstrated the riskScore was a robust and independent prognostic biomarker, and its value in predicting immunotherapeutic outcomes was also confirmed (HR 1.70(1.22–2.37)). This study reveal a novel gene signature significantly related to patient prognosis and TME cell infiltration in LUAD. We demonstrated the integrated roles of multiple key molecules played a crucial role in shaping TME cell infiltration diversity and complexity. Evaluating the integrated characterization of multiple key molecules could contribute to predicting patients' response to immunotherapy and guiding more effective immunotherapy strategies.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
芳泽发布了新的文献求助10
1秒前
su发布了新的文献求助10
2秒前
Milou完成签到,获得积分10
3秒前
3秒前
老阎应助科研通管家采纳,获得30
3秒前
orixero应助科研通管家采纳,获得10
4秒前
汉堡包应助科研通管家采纳,获得10
4秒前
4秒前
小马甲应助科研通管家采纳,获得10
4秒前
科研白菜白完成签到,获得积分10
4秒前
慕青应助科研通管家采纳,获得10
4秒前
大模型应助科研通管家采纳,获得10
4秒前
无花果应助科研通管家采纳,获得10
4秒前
英俊的铭应助科研通管家采纳,获得20
4秒前
4秒前
SciGPT应助科研通管家采纳,获得10
4秒前
科研乞丐应助科研通管家采纳,获得20
4秒前
jjj应助科研通管家采纳,获得20
4秒前
小二郎应助科研通管家采纳,获得10
4秒前
小马甲应助科研通管家采纳,获得30
4秒前
桐桐应助科研通管家采纳,获得10
4秒前
ding应助科研通管家采纳,获得10
4秒前
4秒前
烟花应助科研通管家采纳,获得10
4秒前
4秒前
4秒前
4秒前
充电宝应助科研通管家采纳,获得10
4秒前
zpt完成签到,获得积分10
5秒前
爱学习的瑞瑞子完成签到 ,获得积分10
5秒前
pauchiu完成签到,获得积分0
5秒前
jay完成签到,获得积分10
5秒前
6秒前
7秒前
8秒前
xixi完成签到 ,获得积分10
8秒前
杜熙完成签到,获得积分10
8秒前
10秒前
11秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038619
求助须知:如何正确求助?哪些是违规求助? 3576294
关于积分的说明 11375058
捐赠科研通 3306084
什么是DOI,文献DOI怎么找? 1819374
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066