医学
心脏病学
四分位间距
内科学
危险系数
再狭窄
药物洗脱支架
置信区间
血管成形术
支架
临床终点
狭窄
曲线下面积
心肌梗塞
析因分析
接收机工作特性
随机对照试验
作者
Lili Liu,Fenghua Ding,Juan Luis Gutiérrez‐Chico,Jinzhou Zhu,Zhengbin Zhu,Run Du,Zhenkun Yang,Jian Hu,Shengxian Tu,Ruiyan Zhang
出处
期刊:Cardiology Journal
[VM Media Sp zo.o. - VMGroup SK]
日期:2021-11-23
卷期号:30 (2): 167-177
被引量:9
标识
DOI:10.5603/cj.a2021.0154
摘要
Background: Investigating the prognostic value of the Murray law-based quantitative flow ratio (μQFR) on the clinical outcome after treatment of in-stent restenosis (ISR) with a drug-coated balloon (DCB). Methods: Patients participating in a previous randomized clinical trial for DCB-ISR were post-hoc analyzed. The primary endpoint was vessel-oriented composite endpoint (VOCE), defined as cardiac death, target vessel-related myocardial infarction, and ischemia-driven target vessel revascularization. μQFRs at baseline and after DCB angioplasty was calculated, and its prognostic value as a predictor of VOCE was explored in Cox regression. Results: A total of 169 lesions in 169 patients were analyzed. At one-year follow-up, 20 VOCEs occurred in 20 patients. Receiver-operating characteristic curve analysis identified a post-procedural μQFR of ≤ 0.89 as the best cut-off to predict VOCE (area under curve [AUC]: 0.74; 95% confidence interval [CI]: 0.67–0.80; p < 0.001), superior to post-procedural in-stent percent diameter stenosis (DS), which reported an AUC of 0.61 (95% CI: 0.53–0.68; p = 0.18). Post-procedural μQFR was significantly lower in patients with VOCE compared with those without (0.88 [interquartile range: 0.79–0.94] vs. 0.96 [interquartile range: 0.91–0.98], respectively; p < 0.001). After correction for potential confounders, post-procedural μQFR ≤ 0.89 was associated with a 6-fold higher risk of VOCE than lesions with μQFR > 0.89 (hazard ratio: 5.94; 95% CI: 2.33–15.09; p < 0.001). Conclusions: Post-procedural μQFR may become a promising predictor of clinical outcome after treatment of DES-ISR lesions by DCB angioplasty.
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