生物膜
生物
多药耐受
抗菌剂
微生物学
抗生素
免疫系统
持久性(不连续性)
细菌
抗生素耐药性
免疫学
遗传学
工程类
岩土工程
作者
Oana Ciofu,Claus Moser,Peter Østrup Jensen,Niels Høiby
标识
DOI:10.1038/s41579-022-00682-4
摘要
Chronic infections caused by microbial biofilms represent an important clinical challenge. The recalcitrance of microbial biofilms to antimicrobials and to the immune system is a major cause of persistence and clinical recurrence of these infections. In this Review, we present the extent of the clinical problem, and the mechanisms underlying the tolerance of biofilms to antibiotics and to host responses. We also explore the role of biofilms in the development of antimicrobial resistance mechanisms.
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