突触发生
钙粘蛋白
神经科学
细胞生物学
生物
突触可塑性
突触形成
突触
连环素
细胞粘附
细胞内
细胞粘附分子
信号转导
受体
细胞
Wnt信号通路
遗传学
作者
Jyothi Arikkath,Louis F. Reichardt
标识
DOI:10.1016/j.tins.2008.07.001
摘要
Synapse formation involves reciprocal interactions between cells resulting in formation of a structure optimized for efficient information transfer. Recent work has implicated constituents of the cadherin-catenin cell-adhesion complex in both synapse formation and plasticity. In this review, we describe recent interesting discoveries on mechanisms of cadherin complex function, in addition to regulating adhesion, that are relevant for understanding the role of this complex in synaptogenesis and plasticity. We describe how this complex acts via (i) recruitment/stabilization of intracellular partners; (ii) regulation of intracellular signaling pathways; (iii) regulation of cadherin surface levels, stability and turnover; (iv) stabilization of receptors; and (v) regulation of gene expression. These exciting discoveries provide insights into novel functional roles of the complex beyond regulating cell adhesion.
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