生物
细胞生物学
细胞凋亡
程序性细胞死亡
秀丽隐杆线虫
细胞
免疫系统
平衡
凋亡细胞死亡
免疫学
遗传学
基因
标识
DOI:10.1016/j.tcb.2003.10.004
摘要
Efficient elimination of cells undergoing programmed cell death is crucial for normal tissue homeostasis and for the regulation of immune responses. This review examines unique signals presented by apoptotic cells and the mechanisms by which phagocytes recognize and respond to these signals to orchestrate the selective and rapid removal of apoptotic cells. Such unique signals include direct and indirect 'eat-me' markers on the apoptotic cell surface, the absence of 'don't eat-me' markers normally found on living cells and soluble 'come-get-me' signals secreted by apoptotic cells to attract phagocytes to sites of apoptotic cell death. Once apoptotic cells are identified, their uptake by phagocytes further depends on the molecular machinery highly conserved from Caenorhabditis elegans to mammals.
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