反应性(心理学)
磷酰胺
四唑
化学
产量(工程)
氨基酸
肽
组合化学
磷酸化
有机化学
生物化学
医学
材料科学
冶金
替代医学
病理
DNA
寡核苷酸
作者
Shuibing Chen,Yanmei Li,Shunzhong Luo,Gang Zhao,Bo Tan,Yufen Zhao
标识
DOI:10.1080/10426500008045253
摘要
Abstract O-phosphorylated peptide and amino acid are important in living system. In this paper, Dialkyl-N,N-dialkyl phosphoramidites (DDPA) 3 were synthesized using two methods. The reaction of DDPA with the hydroxyl group of the corresponding amino acids in the presence of tetrazole, followed by oxidation, gave O-phosphoryl amino acid methyl esters in a good yield. A systematical study of the reactivity of DDPA was presented too.
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