对映选择合成
催化作用
卤化
化学
透视图(图形)
卤素
领域(数学)
组合化学
有机化学
计算机科学
数学
人工智能
纯数学
烷基
作者
Scott E. Denmark,William Kuester,Matthew T. Burk
标识
DOI:10.1002/anie.201204347
摘要
Despite the fact that halogenation of alkenes has been known for centuries, enantioselective variants of this reaction have only recently been developed. In the past three years, catalytic enantioselective versions of halofunctionalizations with the four common halogens have appeared and although important breakthroughs, they represent just the very beginnings of a nascent field. This Minireview provides a critical analysis of the challenges that accompany the development of general and highly enantioselective halofunctionalization reactions. Moreover, the focus herein, diverges from previous reviews of the field by identifying the various modes of catalysis and the different strategies implemented for asymmetric induction.
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