类有机物
结直肠癌
肿瘤微环境
精密医学
转化研究
医学
个性化医疗
肿瘤异质性
癌症
药物开发
癌症研究
生物信息学
计算生物学
生物
病理
药品
内科学
神经科学
药理学
作者
Jingwei Li,Jianhua Liu,Wuzheng Xia,Hongwei Yang,Weihong Sha,Hao Chen
标识
DOI:10.1177/15330338231221856
摘要
Colorectal cancer (CRC) is one of the most prevalent malignant tumors of the digestive tract worldwide. Despite notable advancements in CRC treatment, there is an urgent requirement for preclinical model systems capable of accurately predicting drug efficacy in CRC patients, to identify more effective therapeutic options. In recent years, substantial strides have been made in the field of organoid technology, patient-derived organoid models can phenotypically replicate the original intra-tumor and inter-tumor heterogeneity of CRC, reflecting cellular interactions of the tumor microenvironment. Patient-derived organoid models have become an indispensable tool for investigating the pathogenesis of CRC and facilitating translational research. This review focuses on the application of organoid technology in CRC modeling, tumor microenvironment, and guiding clinical treatment, particularly in drug screening and personalized medicine. It also examines the existing challenges encountered in clinical organoid research and provides a prospective outlook on the future development directions of clinical organoid research, encompassing the standardization of organoid culture technology and the application of tissue engineering technology.
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