The Botany, Phytochemistry, Pharmacology, Toxicology, and Quality Control of Epimedium: A Review

: Epimedium has long been used as an ethnic drug in Asia and Europe for its high medicinal value and health benefits, which is often used for anti-tumor, anti-osteoporosis, sexual dysfunction, and other related diseases. In this research, Epimedium isreviewed in the botany, phytochemistry, pharmacology, toxicology, processing, and quality control to make it better for clinical services. More than 106 compounds, including flavonoids, polysaccharides, alkaloids, lignans, and others, were isolated from Epimedium. Based on multiple chemically active components, Epimedium has a wide range of pharmacological action. Several studies have demonstrated Epimedium has multiple biological activities, including neuroprotective effects, anti-inflammatory, anti-aging, and antioxidant effects, anti-osteoporosis, anti-cancer, anti-tumor, anti-diabetes, anti-influenza, effects on sexual dysfunction, etc. Recently, the toxicity of Epimedium has been brought into focus, and its hepatotoxicity has been confirmed through animal experiments. Moreover, it is particularly important to control its quality. To date, great progress has been made in the study of Epimedium. This study systematically reviews the achievements of research on Epimedium. Moreover, the shortcomings of the current research on Epimedium were pointed out, and some suggestions were given.