BAP1型
肾细胞癌
肾透明细胞癌
免疫疗法
癌症研究
生物标志物
肾癌
癌
细胞
医学
生物
肿瘤科
内科学
病理
癌症
遗传学
黑色素瘤
作者
Payal Kapur,Satwik Rajaram,James Brugarolas
标识
DOI:10.1016/j.humpath.2022.07.022
摘要
Mutations drive renal cell carcinoma biology and tumor growth. The BRCA1-associated protein-1 (BAP1) gene is frequently mutated in clear cell renal cell carcinoma (ccRCC) and has emerged as a prognostic and putative predictive biomarker. In this review, we discuss the role of BAP1 as a signature event of a subtype of ccRCC marked by aggressiveness, inflammation, and possibly a heightened response to immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI