清脆的
肠沙门氏菌
生物
微生物学
病菌
抗生素
沙门氏菌
大肠杆菌
细菌
计算生物学
遗传学
基因
作者
Zihao Song,Yue Yu,Xinpeng Bai,Yiguo Jia,Jiayi Tian,Kui Gu,Mengyu Zhao,Changyu Zhou,Xiangyu Zhang,Hongning Wang,Yizhi Tang
标识
DOI:10.1128/spectrum.01300-22
摘要
Antibiotics with broad-spectrum activities are known to disturb both pathogens and beneficial gut microbiota and cause many undesired side effects, prompting increased interest in developing therapies that specifically eliminate pathogenic bacteria without damaging gut resident flora. To achieve this goal, we developed a strategy utilizing bacterial conjugation to deliver CRISPR-Cas13a programmed to specifically kill S. Typhimurium.
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