肿瘤微环境
胰腺癌
转化生长因子
癌症研究
细胞因子
癌症
胰腺肿瘤
医学
转化生长因子β
生物
内科学
作者
Qiang Luo,Ziquan Hu,Haixing Zhao,Yanmei Fan,Xiancong Tu,Yueqing Wang,Xiaowen Liu
标识
DOI:10.1016/j.gendis.2022.10.019
摘要
Pancreatic cancer (PC) is an aggressive malignant tumor with low rate of surgical resection and poor prognosis. Transforming growth factor-β (TGF-β) is a cytokine that has both protumor and antitumor activities, depending on tumor microenvironment. The interaction between TGF-β signaling and the tumor microenvironment in PC is complex. Here, we reviewed the role of TGF-β in the tumor microenvironment of PC, highlighting producers of TGF-β and TGF-β responders in the tumor microenvironment of PC.
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