Novel quinoline derivatives as antitumor agents against HepG2 cells: Synthesis, characterization, in silico, in vitro and docking studies

New quinoline derivatives based on the allyl and amino acid were prepared and characterized using elemental analysis, 1HNMR, 13CNMR spectra. Docking studies of synthesized compounds were performed in order to explore their binding with HepG2 (code: 5EQG protein) as human liver carcinoma. Some synthesized compounds were evaluated for them in vitro cytotoxic activity against the hepatic carcinoma cell line (HepG2). Among the tested compounds, compound 15d exhibited the most promising profile, being able to inhibit HepG2 (IC50 = 6.529 µg/ml).