This short review aims to introduce the uniqueness, advantages, and recent progress in using calixarenes for membrane modifications and separations. This type of unique nano-porous materials may provide great prospects for next-generation membrane modifications and development. • Introduction of uniqueness of calixarene incorporated membranes for water reuses. • Summary of recent progress of calixarene embedded membrane for gas separations. • Elucidation of infiltration process for calixarene incorporated membranes. • Perspectives of calixarene embedded membranes for molecular separations.