静脉注射
微泡
上皮-间质转换
外渗
间充质干细胞
癌症研究
癌细胞
表型
鼻涕虫
淋巴系统
癌症
利基
生物
小RNA
转移
细胞生物学
免疫学
基因
生态学
生物化学
遗传学
作者
Jacqueline Banyard,Diane R. Bielenberg
标识
DOI:10.3109/03008207.2015.1060970
摘要
Metastatic cancer cells are lethal. Understanding the molecular mechanisms that bolster the conversion from benign to malignant progression is key for treating these heterogeneous and resistant neoplasms. The epithelial-mesenchymal transition (EMT) is a conserved cellular program that alters cell shape, adhesion and movement. The shift to a more mesenchymal-like phenotype can promote tumor cell intravasation of surrounding blood vessels and emigration to a new organ, yet may not be necessary for extravasation or colonization into that environment. Lymphatic dissemination, on the other hand, may not require EMT. This review presents emerging data on the modes by which tumor cells promote EMT/MET via microRNA and prepare the pre-metastatic niche via exosomes.
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