A Facile One-Pot Conversion of Aldehydes into Nitriles

Abstract A facile one-pot synthesis of nitriles starting with aldehydes has been developed employing hydroxylamine hydrochloride in dimethylsulfoxide at 100°C. Keywords: Aldehydealdoximedehydrationnitriletandem reaction ACKNOWLEDGMENT The authors gratefully acknowledge financial support from the Research Corporation, the University of Chattanooga Foundation, and the Grote Chemistry Fund. Notes a Isolated yields. b Nitrile purities >95% as determined by 1H-NMR. c Monitored by GC-MS.