传统医学
乳腺癌
癌症
药理学
医学
消炎药
三萜类
生物
内科学
作者
Yan Ju,Hui Liang,Kaicheng Du,Zifeng Guo,Dali Meng
标识
DOI:10.1080/14786419.2020.1805603
摘要
Breast cancer (BC) is a cancer with a high incidence and mortality of female, threatening women's physical and mental health. Achyranthes bidentata Blume, a traditional Chinese medicine, has been popular in folk due to its effective pharmacology activities including anti-inflammatory and anti-tumour effects. In order to identify the active ingredients from the roots of A. bidentata for treating breast cancer, the separation guided by network pharmacology analysis was employed which led to the isolation of 7 triterpenoids and 10 phytosterones. According to the in vitro experiments, the isolated compounds showed significant inhibitory activities on MCF-7 cells as well as anti-inflammatory activities by attenuating the production of NO and TNF-α in LPS-induced macrophage cells. In conclusion, this study successfully predicted and confirmed the positive impact of triterpenoids and phytosterones on breast cancer, which provided a foundation for further in vivo studies.
科研通智能强力驱动
Strongly Powered by AbleSci AI