膦酸盐
化学
试剂
重氮甲烷
组合化学
侧链
反应条件
有机化学
催化作用
聚合物
作者
Katarzyna Justyna,Joanna Małolepsza,Damian Kusy,Waldemar Maniukiewicz,K. M. Błażewska
摘要
The McKenna reaction is a well-known and popular method for the efficient and mild synthesis of organophosphorus acids. Bromotrimethylsilane (BTMS) is the main reagent in this reaction, which transforms dialkyl phosphonate esters into bis(trimethylsilyl)esters, which are then easily converted into the target acids. However, the versatile character of the McKenna reaction is not always used to its full extent, due to formation of side products. Herein, demonstrated by using model examples we have not only analyzed the typical side processes accompanying the McKenna reaction, but also uncovered new ones. Further, we discovered that some commonly recommended precautions did not always circumvent the side reactions. The proposed results and recommendations may facilitate the synthesis of phosphonic acids.
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