后代
双相情感障碍
精神分裂症(面向对象编程)
连接体
内表型
功能磁共振成像
心理学
人口
磁共振成像
神经科学
医学
功能连接
精神科
生物
怀孕
遗传学
认知
放射科
环境卫生
作者
Guusje Collin,Lianne H. Scholtens,René S. Kahn,Manon H. J. Hillegers,Martijn P. van den Heuvel
标识
DOI:10.1016/j.biopsych.2017.06.013
摘要
Background Emerging evidence suggests disruptions in the wiring organization of the brain’s network in schizophrenia (SZ) and bipolar disorder (BD). As the importance of genetic predisposition has been firmly established in these illnesses, children (offspring) of patients constitute an at-risk population. This study examines connectome organization in children at familial high risk for psychosis. Methods Diffusion-weighted magnetic resonance imaging scans were collected from 127 nonpsychotic offspring 8 to 18 years of age (average age = 13.5 years) of a parent diagnosed with SZ (SZ offspring; n = 28) or BD (BD offspring; N = 60) and community control subjects (n = 39). Resting-state functional magnetic resonance imaging scans were available for 82 subjects. Anatomical and functional brain networks were reconstructed and examined using graph theoretical analysis. Results SZ offspring were found to show connectivity deficits of the brain’s central rich club (RC) system relative to both control subjects and BD offspring. The disruption in anatomical RC connectivity in SZ offspring was associated with increased modularity of the functional connectome. In addition, increased coupling between structural and functional connectivity of long-distance connections was observed in both SZ offspring and BD offspring. Conclusions This study shows lower levels of anatomical RC connectivity in nonpsychotic young offspring of SZ patients. This finding suggests that the brain’s anatomical RC system is affected in at-risk youths, reflecting a connectome signature of familial risk for psychotic illness. Moreover, finding no RC deficits in offspring of BD patients suggest a differential effect of genetic predisposition for SZ versus BD on the developmental formation of the connectome.
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