生物
遗传学
基因
黑腹果蝇
突变体
遗传筛选
突变
抑制器
表型
蛋白激酶A
激酶
作者
Tian Xu,Weiyi Wang,Sheng Zhang,Rodney A. Stewart,Wan Yu
出处
期刊:Development
[The Company of Biologists]
日期:1995-04-01
卷期号:121 (4): 1053-1063
被引量:765
标识
DOI:10.1242/dev.121.4.1053
摘要
ABSTRACT We have identified recessive overproliferation mutations by screening and examining clones of mutant cells in genetic mosaics of the fruitfly Drosophila melanogaster. This type of screen provides a powerful approach for identifying and studying potential tumor suppressors. One of the identified genes, lats, has been cloned and encodes a putative protein kinase that shares high levels of sequence similarity with three proteins in budding yeast and Neu-rospora that are involved in regulation of the cell cycle and growth. Mutations in lats cause dramatic overproliferation phenotypes and various developmental defects in both mosaic animals and homozygous mutants.
科研通智能强力驱动
Strongly Powered by AbleSci AI