Designing and Pilot Testing a Novel Transcranial Temporal Interference Stimulation Device for Neuromodulation

神经调节 神经科学 刺激 脑深部刺激 经颅直流电刺激 局部场电位 串扰 计算机科学 生物医学工程 电子工程 工程类 医学 生物 帕金森病 疾病 病理
作者
Zhao Zhang,Bor-Shing Lin,Ching-Lin Wu,Tsung‐Hsun Hsieh,Jian‐Chiun Liou,Yuting Li,Chih‐Wei Peng
出处
期刊:IEEE Transactions on Neural Systems and Rehabilitation Engineering [Institute of Electrical and Electronics Engineers]
卷期号:30: 1483-1493 被引量:4
标识
DOI:10.1109/tnsre.2022.3179537
摘要

Transcranial temporal interference stimulation (tTIS) has been proposed as a new neuromodulation technology for non-invasive deep-brain stimulation (DBS). However, few studies have detailed the design method of a tTIS device and provided system validation. Thus, a detailed design and validation scheme of a novel tTIS device for animal brain stimulation are presented in this study. In the proposed tTIS device, a direct digital synthesizer (DDS) was used to generate a sine wave potential of different frequencies, which was converted to an adjustable sine wave current. A current transformer was used to produce electrical isolation of different channels, which eliminated the current crosstalk between channels and greatly increased the load capacity by amplifying the output voltage. Several in vitro experiments were first conducted to validate the tTIS device. Our results indicated that the error percentages of the stimulation currents were within ±2%. Current crosstalk between channels was almost completely eliminated. Then, in vivo electric field measurement shows that the 2-pole arrangement may provide better cortical targeting than the 4-pole mode. A pilot animal experiment was conducted in which evoked motion and electromyographic activation of the contralateral forelimb were observed, which indicated that the 2-pole tTIS had successfully activated the primary motor cortex in a rat. Motor activation induced by the 2-pole tTIS demonstrated the feasibility and safety potential when applying our tTIS device for neuromodulation.

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