医学
水肿
脑水肿
贝伐单抗
环氧合酶
药理学
副作用(计算机科学)
类固醇
内科学
化疗
激素
生物化学
化学
酶
计算机科学
程序设计语言
作者
Patrick Roth,Luca Regli,Michaela Tonder
标识
DOI:10.1586/14737140.2013.852473
摘要
The long-term treatment of peritumoral edema remains a major challenge in clinical neuro-oncology. Steroids have been and will remain the backbone of any anti-edematous therapy because of their striking activity, convenient oral administration and also because of their cost-effectiveness. Their side effects, however, can compromise quality of life, particularly upon continuous administration. Therapeutic alternatives which may replace or - at least - help to reduce the steroid dose are limited. However, with the development of new agents such as corticorelin acetate, there is a hope that steroid-induced side effects can be delayed and reduced. The administration of anti-angiogenic agents with steroid-sparing effects, for example, bevacizumab, is limited due to their costs. Increased knowledge on boswellic acids and cyclooxygenase-2 inhibitors which are available for clinical application may help to exploit their anti-edema activity more efficiently in the future.
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