医学
降钙素原
败血症
多器官功能障碍综合征
感染性休克
机械通风
器官功能障碍
免疫球蛋白M
内科学
胃肠病学
呼吸衰竭
免疫球蛋白G
休克(循环)
抗体
安慰剂
免疫学
病理
替代医学
作者
Ildikó Tóth,A Mikor,Tamás Leiner,Zsolt Molnár,Lajos Bogár,Tamás Szakmány
标识
DOI:10.1007/s00540-012-1553-9
摘要
Mortality due to septic-shock-induced respiratory failure remains high. A recent meta-analysis suggested that IgM-enriched immunoglobulin treatment may be beneficial in these patients. In this prospective randomised controlled pilot study we investigated the effects of IgM-enriched immunoglobulin treatment in patients with early septic shock accompanied by severe respiratory failure. 33 patients were randomly allocated to receive 5 ml/kg (predicted body weight) IgM-enriched immunoglobulin (16 patients) or placebo (17 patients), respectively, via 8 h IV-infusion for three consecutive days. Daily Multiple Organ Dysfunction Scores (MODS) were calculated. Serum C-reactive protein (CRP) and procalcitonin (PCT) levels were monitored daily. For statistical analysis two-way ANOVA was used. Daily MODS showed ongoing multiple system organ failure without significant resolution during the 8 days. Median length of ICU stay, mechanical ventilation, vasopressor support during the ICU stay and 28-day mortality were nearly identical in the two groups. Serum PCT levels showed no significant difference between the two groups, however, CRP levels were significantly lower in the IgM-enriched immunoglobulin group on days 4, 5 and 6, respectively. In this study the use of IgM-enriched immunoglobulin preparation failed to produce any improvement in the organ dysfunction as compared to standard sepsis therapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI