Lisuride Pharmacology and Treatment of Parkinson’s Disease

Lisuride hydrogen maleate [1,1 diethyl-3-(9,10-didehydro-6-methyl-8α-ergolinyl] urea is the first derivative of isolysergic acid in clinical use. It is an 8-α-aminoergoline and was synthesized by Zikan and Semonsky (1968). It is a white slightly bitter tasting substance, which is reasonably stable at room temperature if not exposed to light. Lisuride hydrogen maleate is soluble in water or saline up to 1 mg/ml. Owing to its low effective dose, it is therefore the first dopamine agonist which can also be used on a parenteral basis (Dorow et al. 1980).