前药
溶解度
生化工程
磁导率
药品
化学
药物输送
药理学
计算机科学
工程类
医学
有机化学
生物化学
膜
标识
DOI:10.1016/j.ddtec.2012.04.002
摘要
Today, prodrugs are an important option in any lead optimization program and are being considered as soon as critical hurdles in terms of solubility and permeability are identified. A successful prodrug effort starts with a careful evaluation of the issues and is guided by a detailed stepwise characterization of solubility, stability and permeability to arrive at an efficient optimization process.
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