Clinical Effect Observation of Mechanical Ventilation Combined with Ulinastatin in Treatment of Acute Respiratory Distress Syndrome

Objective: To observe the clinical effect of mechanical ventilation combined with ulinastatin in treatment of acute respiratory distress syndrome. Methods: Date of Sixty patients with acute respiratory distress syndrome were retrospectively analyzed, treatment group(30 cases) were treated using mechanical ventilation combined with ulinastatin; control group(30 cases) were treated using mechanical ventilation, then the respiratory frequency, PaO2, PaO2/FiO2, PCO2, APACHEII scores, chest radiograph change, VAP incidence and mortality in the two groups were observed. Results: Respiratory frequency, PaO2, PaO2/FiO2and PCO2in treatment group were better than those in control group(t=6.39, 6.27, 24.07, 9.82,P0.05); VAP incidence was 20.0% in treatment group, and was less than 36.7% in control group( X2=5.84, P=0.0160.05); mortality(3.3%) in treatment group was less than 16.7% in control group(X2= 5.71, P=0.0170.05). APACHEII scores and chest X-ray changes between the two groups had obvious difference(t=7.14, 6.33, P 0.05). Conclusion: The clinical effect of mechanical ventilation combined with ulinastatin in treatment of acute respiratory distress syndrome is good; the treatment can improve lung function, alleviates the symptoms, improves the safety and reliability and controls the mortality.