利福平
化学
rpoB公司
分子生物学
RNA依赖性RNA聚合酶
DNA聚合酶
RNA聚合酶Ⅰ
RNA聚合酶Ⅱ
抄写(语言学)
结核分枝杆菌
病毒学
逆转录酶
作者
Hamed Mosaei,Nikolay Zenkin
出处
期刊:Ecosal plus
[American Society for Microbiology]
日期:2020-04-01
卷期号:9 (1)
被引量:3
标识
DOI:10.1128/ecosalplus.esp-0017-2019
摘要
RNA polymerases (RNAPs) accomplish the first step of gene expression in all living organisms. However, the sequence divergence between bacterial and human RNAPs makes the bacterial RNAP a promising target for antibiotic development. The most clinically important and extensively studied class of antibiotics known to inhibit bacterial RNAP are the rifamycins. For example, rifamycins are a vital element of the current combination therapy for treatment of tuberculosis. Here, we provide an overview of the history of the discovery of rifamycins, their mechanisms of action, the mechanisms of bacterial resistance against them, and progress in their further development.
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