生物
脱氮酶
泛素
表观遗传学
病毒感染
功能(生物学)
癌变
细胞生物学
蛋白酶
病毒蛋白
病毒学
遗传学
病毒
癌症
酶
基因
生物化学
作者
Anna Bojagora,V. Saridakis
出处
期刊:Virus Research
[Elsevier]
日期:2020-09-01
卷期号:286: 198076-198076
被引量:14
标识
DOI:10.1016/j.virusres.2020.198076
摘要
Ubiquitin Specific Protease 7 (USP7) is a deubiquitinating enzyme (DUB) that plays critical roles in the regulation of many cellular processes including epigenetics, tumour suppression, oncogenesis, DNA damage response, immunity and viral infection. USP7 was the first DUB associated with viral infection. Since then other DUB:viral protein interactions have been discovered, however, USP7 continues to be the most targeted DUB interacting with many proteins from various viruses. The selective pressures of evolution have allowed viruses to develop mechanisms that subvert host cellular machinery, promoting survival of the viral niche. Numerous viral proteins have been identified to target and usurp the function of USP7 to their advantage. This review explores novel developments in research focusing on the mechanisms underlying the manipulation of USP7 by viruses.
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