胞间连丝
细胞生物学
糖
生物
植物细胞
TOR信号
遗传筛选
生物化学
细胞
植物
信号转导
基因
表型
作者
Jacob O. Brunkard,Min Xu,M. Regina Scarpin,Snigdha Chatterjee,Elena A. Shemyakina,Howard M. Goodman,Patricia Zambryski
标识
DOI:10.1073/pnas.1919196117
摘要
The coordinated redistribution of sugars from mature “source” leaves to developing “sink” leaves requires tight regulation of sugar transport between cells via plasmodesmata (PD). Although fundamental to plant physiology, the mechanisms that control PD transport and thereby support development of new leaves have remained elusive. From a forward genetic screen for altered PD transport, we discovered that the conserved eukaryotic glucose-TOR (TARGET OF RAPAMYCIN) metabolic signaling network restricts PD transport in leaves. Genetic approaches and chemical or physiological treatments to either promote or disrupt TOR activity demonstrate that glucose-activated TOR decreases PD transport in leaves. We further found that TOR is significantly more active in mature leaves photosynthesizing excess sugars than in young, growing leaves, and that this increase in TOR activity correlates with decreased rates of PD transport. We conclude that leaf cells regulate PD trafficking in response to changing carbohydrate availability monitored by the TOR pathway.
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