医学
空气污染
环境卫生
微粒
污染
公共卫生
颁布
气候变化
心血管健康
风险评估
疾病
内科学
病理
生物
计算机科学
有机化学
化学
法学
计算机安全
生态学
政治学
作者
Sanjay Rajagopalan,Sadeer Al‐Kindi,Robert D. Brook
标识
DOI:10.1016/j.jacc.2018.07.099
摘要
Fine particulate matter <2.5 μm (PM2.5) air pollution is the most important environmental risk factor contributing to global cardiovascular (CV) mortality and disability. Short-term elevations in PM2.5 increase the relative risk of acute CV events by 1% to 3% within a few days. Longer-term exposures over several years increase this risk by a larger magnitude (∼10%), which is partially attributable to the development of cardiometabolic conditions (e.g., hypertension and diabetes mellitus). As such, ambient PM2.5 poses a major threat to global public health. In this review, the authors provide an overview of air pollution and health, including assessment of exposure, impact on CV outcomes, mechanistic underpinnings, and impact of air pollution reduction strategies to mitigate CV risk. The review concludes with future challenges, including the inextricable link between air pollution and climate change, and calls for large-scale trials to allow the promulgation of formal evidence-based recommendations to lower air pollution-induced health risks.
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