Serum Pharmacochemistry of Traditional Chinese Medicine

Serum pharmacochemistry is a new discipline that has rapidly developed over the years, but its successful practice can be traced back to the invention of sulfonamides by Gerhard Domagk. German scientists synthesized a drug called prontosil in the 1930s, but it did not show the bactericidal effect in vitro. Domagk found that prontosil did not exert its effect in vitro, while injection in animal models was effective. His further research found that prontosil produced sulfonamides by an in vivo metabolism, and this metabolite had a bactericidal effect. This practice should have been an important development in drug in vivo research, but for a long period of time, regrettably a system methodology was not established.