Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunity

(Immunity 55, 1268–1283.e1–e9; July 12, 2022) We overlooked a related study that was published during the resubmission of the manuscript. This study shows that a greater frequency of incidence as well as greater severity of renal carcinoma in male patients can be attributed to androgen receptor-driven exhaustion in the CD8+ T cell compartment. We have now acknowledged this study in the discussion and have cited it accordingly. Androgen receptor-mediated CD8+ T cell stemness programs drive sex differences in antitumor immunityYang et al.ImmunityJune 13, 2022In BriefMost non-reproductive human cancers exhibit sex differences, but the underlying immunological mechanism remains unknown. Yang et al. identify that AR signaling accelerates the transition from stem cell-like CD8+ T cells to terminally exhausted CD8+ T cells in males, leading to sex-biased antitumor immunity, whereas AR signaling inhibition reprograms CD8+ T cells into a stem cell-like state to potentiate cancer immunotherapy. Full-Text PDF