Structure, mechanism, and toxicity in antibiotics metal complexation: Recent advances and perspectives

Antibiotic–metal complexes (AMCs) formed by antibiotics and metal ions have attracted considerable attentions in recent years. Although different removal methods for AMCs have been reported in the literature, very few investigations have focused on the mechanisms and toxic effects of antibiotic–metal coordination. This review briefly describes the structural characteristics of various commonly used antibiotics and the coordination mechanisms with metal ions. Considering the complexity of the real environment, various environmental factors affecting AMC formation are highlighted. The effects of AMCs on microbial community structure and the role of metal ions in influencing resistant genes from the molecular perspective are of interest within this work. The toxicities and mechanisms of AMCs on different species of biota are also discussed. These findings underline the need for more targeted detection and analysis methods and more suitable toxicity markers to verify the combination of antibiotics with metal ions and reveal environmental toxicities in future. This review presents an innovative idea that antibiotics combined with metal ions will change the toxicity and environmental behavior of antibiotics.