HERV-W envelope protein is present in microglial cells of the human glioma tumor microenvironment and differentially modulates neoplastic cell behavior

生物 胶质瘤 肿瘤微环境 细胞生物学 小胶质细胞 包络线(雷达) 癌症研究 肿瘤细胞 免疫学 炎症 电信 雷达 计算机科学
作者
Laura Reiche,Benedikt Plaack,Maren Lehmkuhl,Vivien Weyers,Joel Gruchot,Daniel Picard,Hervé Perron,Marc Remke,Christiane B. Knobbe‐Thomsen,Guido Reifenberger,Patrick Küry,David Kremer
出处
期刊:Microbes and Infection [Elsevier]
卷期号:: 105460-105460
标识
DOI:10.1016/j.micinf.2024.105460
摘要

Gliomas are the most common parenchymal tumors of the central nervous system (CNS). With regard to their still unclear etiology, several recent studies have provided evidence of a new category of pathogenic elements called human endogenous retroviruses (HERVs) which seem to contribute to the evolution and progression of many neurological diseases such as amyotrophic lateral sclerosis (ALS), schizophrenia, chronic inflammatory polyneuropathy (CIDP) and, particularly, multiple sclerosis (MS). In these diseases, HERVs exert effects on cellular processes such as inflammation, proliferation, and migration. In previous studies, we demonstrated that in MS, the human endogenous retrovirus type-W envelope protein (HERV-W ENV) interferes with lesion repair through the activation of microglia (MG), the innate myeloid immune cells of the CNS. Here, we now show that HERV-W ENV is also present in the microglial cells (MG) of the tumor microenvironment (TME) in gliomas. It modulates the behavior of glioblastoma (GBM) cell lines in GBM/MG cocultures by altering their gene expression, secreted cytokines, morphology, proliferation, and migration properties and could thereby contribute to key tumor properties.
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